Machine learning analysis of humoral and cellular responses to SARS-CoV-2 infection in young adults.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces B and T cell responses, contributing to virus neutralization. In a cohort of 2,911 young adults, we identified 65 individuals who had an asymptomatic or mildly symptomatic SARS-CoV-2 infection and characterized their humoral and T cell responses to the Spike (S), Nucleocapsid (N) and Membrane (M) proteins. We found that previous infection induced CD4 T cells that vigorously responded to pools of peptides derived from the S and N proteins. By using statistical and machine learning models, we observed that the T cell response highly correlated with a compound titer of antibodies against the Receptor Binding Domain (RBD), S and N. However, while serum antibodies decayed over time, the cellular phenotype of these individuals remained stable over four months. Our computational analysis demonstrates that in young adults, asymptomatic and paucisymptomatic SARS-CoV-2 infections can induce robust and long-lasting CD4 T cell responses that exhibit slower decays than antibody titers. These observations imply that next-generation COVID-19 vaccines should be designed to induce stronger cellular responses to sustain the generation of potent neutralizing antibodies.

Hábitos de actividad física, bienestar y calidad de vida durante el aislamiento preventivo por Covid-19 en Bogotá, Colombia (Physical activity habits, well-being, and quality of life during Covid-19 preventive isolation in Bogotá, Colombia)

The Covid-19 pandemic forced the world population to incorporate prevention activities into their daily lives to preserve people's physical health. In Colombia, the national government, through resolutions and decrees, regulated quarantine and preventive isolation in order not to saturate health services and intensive care units, which were not prepared to respond to the disease. In this sense, this article analyzed the habits of physical activity, well-being, and quality of life in preventive isolation - Covid-19 in Bogotá, Colombia. A cross-sectional descriptive quantitative study was conducted on a sample of 1,775 people with an average age of 43.5±25.5 years, of which 50.9% (n=903) corresponded to women and 49.1% (n=872) to men. It was found that due to the confinement the consumption of coffee and alcoholic beverages increased, as well as a decrease in physical activity. In addition, manifestations of anxiety, depression and feelings of loneliness were identified, which directly affected people's well-being and quality of life. It is expected that this type of research will contribute to the understanding of the impact of the contingency measures taken by the different nations to curb Covid-19 infections on people's health. Key words: physical activity, habits, quality of life, quarantine, Covid-19. Alternate :La pandemia por Covid-19 obligó a la población mundial a incorporar a su cotidianidad actividades de prevención para preservar la salud física de las personas. En Colombia, el gobierno nacional a partir de resoluciones y decretos reglamentó la cuarentena y el aislamiento preventivo para no saturar los servicios de salud y las unidades de cuidados intensivos, los cuales no estaban preparados para responder a la enfermedad. En ese sentido, este artículo analizó los hábitos de actividad física, bienestar y calidad de vida en el aislamiento preventivo – Covid-19 en Bogotá, Colombia. Se realizó un estudio cuantitativo descriptivo de corte transversal a una muestra de 1.775 personas con un promedio de edad 43,5±25,5 años, de los cuales el 50,9% (n=903) corresponden a mujeres y el 49,1% (n=872) a hombres. Se encontró que a causa del confinamiento el consumo de café y bebidas alcohólicas aumentó, como también se disminuyó la realización de actividad física. Así mismo se identificaron manifestaciones de ansiedad, depresión y sentimientos de soledad, lo que afectó directamente el bienestar y calidad de vida de las personas. Se espera que este tipo de investigaciones aporten a la comprensión el impacto que tuvieron las medidas de contingencia tomadas por las distintas naciones, para frenar los contagios por Covid-19, en la salud de las personas.Alternate :A pandemia de Covid-19 obrigou a população mundial a incorporar atividades de prevenção em seu cotidiano para preservar a saúde física das pessoas. Na Colômbia, o governo nacional, com base em resoluções e decretos, regulamentou a quarentena e o isolamento preventivo para não saturar os serviços de saúde e as unidades de terapia intensiva, que não estavam preparados para responder à doença. Nesse sentido, este artigo analisou os hábitos de atividade física, bem-estar e qualidade de vida no isolamento preventivo - Covid-19 em Bogotá, Colômbia. Foi realizado um estudo quantitativo descritivo transversal com amostra de 1.775 pessoas com idade média de 43,5±25,5 anos, sendo 50,9% (n=903) mulheres e 49,1% (n=872) homens. Verificou-se que devido ao confinamento o consumo de café e bebidas alcoólicas aumentou, assim como a realização de atividade física diminuiu. Da mesma forma, foram identificadas manifestações de ansiedade, depressão e sentimentos de solidão, que afetaram diretamente o bem-estar e a qualidade de vida das pessoas. Espera-se que este tipo de investigação contribua para a compreensão do impacto que as medidas de contingência tomadas pelas diferentes nações tiveram na saúde das pessoas para travar a propagação da Covid-19. Palavras-chave: atividade física, hábitos, qualid de de vida, quarentena, Covid-19.